Single nucleotide polymorphisms in colorectal cancer: associations with tumor site and TNM stage.
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Mates IN, Jinga V, Csiki IE, Mates D, Dinu D, Constantin A, Jinga M. Familial risk for colorectal cancers are mainly due to heritable causes. Environmental and heritable factors in the causation of cancer-analyses of cohorts of twins from Sweden, Denmark, and Finland. Lichtenstein P, Holm NV, Verkasalo PK, Iliadou A, Kaprio J, Koskenvuo M, Pukkala E, Skytthe A, Hemminki K. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012.
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2014 64:104–117.įerlay J, Steliarova-Foucher E, Lortet-Tieulent J, Rosso S, Coebergh JW, Comber H, Forman D, Bray F. GWAS colorectal cancer meta-analysis single nucleotide polymorphism. Sensitivity analyses and publication bias assessment indicated the robust stability and reliability of the results. Heterogeneity among studies and publication bias were assessed by the χ2-based Q statistic test Begg's funnel plot or Egger's test, respectively.Our meta-analysis confirmed significant associations of the five SNPs with CRC risk under different genetic models. Then meta-analyses based on larger sample sizes with average of 33,000 CRC cases and 34,000 controls were performed to assess the association between SNPs and CRC risk.
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Due to the heterogeneity of the studied subjects and the contrary results, it is challenging to verify the certainty of the association between these loci and CRC.We conducted a critical review of the published studies of SNPs associated with CRC. Comprehensive Meta Analysis Keygen Crack Software AuthorBatoolTotal downloads 8636UploadedChecked Dr. Genome-wide association studies (GWAS) on colorectal cancer (CRC) have identified dozens of single nucleotide polymorphisms (SNPs) in more than 19 independent loci associated with CRC.